منابع مشابه
Discrete Gene Replication Events Drive Coupling between the Cell Cycle and Circadian Clocks
Many organisms possess both a cell cycle to control DNA replication and a circadian clock to anticipate changes between day and night. In some cases, these two rhythmic systems are known to be coupled by specific, cross-regulatory interactions. Here, we use mathematical modeling to show that, additionally, the cell cycle generically influences circadian clocks in a non-specific fashion: The reg...
متن کاملDiscrete gene replication events drive coupling between the cell cycle and circadian clocks.
Many organisms possess both a cell cycle to control DNA replication and a circadian clock to anticipate changes between day and night. In some cases, these two rhythmic systems are known to be coupled by specific, cross-regulatory interactions. Here, we use mathematical modeling to show that, additionally, the cell cycle generically influences circadian clocks in a nonspecific fashion: The regu...
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We recently proposed a detailed model describing the dynamics of the network of cyclin-dependent kinases (Cdks) driving the mammalian cell cycle (Gérard and Goldbeter, 2009). The model contains four modules, each centered around one cyclin/Cdk complex. Cyclin D/Cdk4-6 and cyclin E/Cdk2 promote progression in G1 and elicit the G1/S transition, respectively; cyclin A/Cdk2 ensures progression in S...
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We propose a model that generates an economic expansion following good news about future total factor productivity (TFP) or investmentspecific technical change. The model has three key elements: variable capital utilization, adjustment costs to investment, and preferences that exhibit a weak short-run wealth effect on the labor supply. These preferences nest, as special cases, the two classes o...
متن کاملCell cycle and apoptosis: A review
Cancer is characterized by abnormally excessive cell proliferation. Cell proliferation, the process by which a cell grows and divides to produce two daughter cells. Each of these daughter cells divides to produce two new cells, steps that are called cell cycle. Meanwhile, apoptosis is a highly regulated process of cell death, which is involved not only in the development of shape and morphogene...
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ژورنال
عنوان ژورنال: Journal of Cell Biology
سال: 2005
ISSN: 1540-8140,0021-9525
DOI: 10.1083/jcb1695iti2